OC 41 - Inhibitors, genetics and mechanisms

Moderator(s)

• 

  Ilja Oomen, MD

  MD
  Department of Pediatric Hematology, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands
  Amsterdam, Noord-Holland, Netherlands
• 

  Robert Sidonio, Jr., MD, M.Sc.

  Associate Professor of Pediatrics
  Emory University
  Decatur, Georgia, United States

Presentations:

• 14:45 – 15:00 ICT

  Cluster of deleterious variants in A3 domain of factor VIII in patients with haemophilia A and inhibitors
  

  Co-Author: LUCIANA Werneck Zuccherato – Postdoctoral research

  Co-Author: Ricardo Mesquita Camelo, MD, MBA, MSc, PhD, PostD – Department of Internal Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil

  Co-Author: Maíse Moreira Dias – Faculty of Medicine, Universidade Federal de Minas Gerais (UFMG)

  Co-Author: Márcio Portugal – Hemominas

  Co-Author: Letícia Lemos Jardim – UFMG

  Co-Author: Andréa Oliveira – Fundação Hemominas, Belo Horizonte, Brazil

  Co-Author: Rosângela de Albuquerque Ribeiro – Centro de Hematologia e Hemoterapia do Ceará (HEMOCE)

  Co-Author: Vivian Karla Brognoli Franco – Faculty of Medicine, Universidade Federal de Santa Catarina, Florianópolis, Brazil

  Co-Author: Maria do Rosário Ferraz Roberti – Faculty of Medicine, Universidade Federal de Goiás (UFG)

  Co-Author: Fabia Michelle Rodrigues de Araújo Callado – HEMOPE

  Co-Author: Leina Yukari Etto – Hemoiba

  Co-Author: Maria Aline Ferreira De Cerqueira – HEMOPI

  Co-Author: Monica Cerqueira – Hemocentro do Estado do Rio de Janeiro (HEMORIO), Rio de Janeiro, RJ, Brasil

  Co-Author: Claudia Santos Lorenzato – Centro de Hematologia e Hemoterapia do Paraná (Hemepar), Curitiba, PR, Brasil

  Co-Author: Ieda Solange De Souza Pinto – Hemopa

  Co-Author: Andrea Aparecida Garcia – Hemocentro de São José do Rio Preto

  Co-Author: Tânia Hissa Anegawa – HEMEPAR

  Co-Author: Daniele Campos Fontes Neves – FHEMERON

  Co-Author: Daniel Gonçalves Chaves – Hemominas

  Presenting Author: Suely M. Rezende, MD, PhD – Universidade Federal de Minas Gerais
• 15:00 – 15:15 ICT

  F8 mutations involving deletion of the F8B gene increase inhibitor risk for hemophilia A
  

  Presenting Author: Jie Sun, MD – Hemophilia Comprehensive Care Center,Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health

  Co-Author: Zekun Li, PhD – Department II of Hematology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, 100045, China

  Co-Author: Jialu Zhang – Department II of Hematology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, 100045, China

  Co-Author: Zhenping Chen – Hematologic Diseases Laboratory, Hematology Center, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children’s Health, Beijing, 100045, ChinaChildren’s Health, Beijing, 100045, China

  Co-Author: Runhui Wu, PhD, MD – Department of Hematology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, 100045, China
• 15:15 – 15:30 ICT

  Single-cell sequencing of PBMCs from hemophilia A and hemophilia B patients with inhibitors reveals different immune responses to FVIII and FIX after replacement therapy
  

  Presenting Author: Enhao Li – Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

  Co-Author: Jing Dai – Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

  Co-Author: Zhenping Chen – Hematologic Diseases Laboratory, Hematology Center, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children’s Health, Beijing, 100045, ChinaChildren’s Health, Beijing, 100045, China

  Co-Author: Yilun Xue – Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

  Co-Author: Haoyang Wu – Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

  Co-Author: Zekun Li, PhD – Department II of Hematology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, 100045, China

  Co-Author: Can Lou – Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

  Co-Author: Runhui Wu, PhD, MD – Department of Hematology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, 100045, China

  Co-Author: Xuefeng Wang – Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

  Co-Author: Wenman Wu – Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
• 15:30 – 15:45 ICT

  Patient anti-FVIII drug antibodies bind preferentially to a subset of FVIII covalent forms
  

  Co-Author: Diego Butera – The Centenary Institute, University of Sydney

  Co-Author: Manuela Flórido – Centenary Institute

  Presenting Author: Aster E. Pijning, MSc, PhD – Centenary Institute

  Co-Author: Carmen Coxon – National Institute for Biological Standards and Control

  Co-Author: Clive Metcalfe – National Institute for Biological Standards and Control

  Co-Author: Philip J. Hogg – The Centenary Institute, University of Sydney
• 15:45 – 16:00 ICT

  Evaluation of factor VIII inhibitor risk under emicizumab prophylaxis using hemophilia A murine models with long-term expression of human factors IX and X
  

  Presenting Author: Sheng-Chieh Chou, MD. – Department of Internal Medicine, National Taiwan University Hospital

  Co-Author: Yen-Ting Chang – Department of Clinical Laboratory Science and Medical Biotechnology, National Taiwan University

  Co-Author: Chien-Hong Liu – Department of Clinical Laboratory Science and Medical Biotechnology, National Taiwan University

  Co-Author: Li-Fu Chen – Department of Clinical Laboratory Science and Medical Biotechnology, National Taiwan University

  Co-Author: Guey-Yueh Shi – Department of Biochemistry and Molecular Biology, National Cheng Kung University

  Co-Author: Hua-Lin Wu – Department of Biochemistry and Molecular Biology, National Cheng Kung University

  Co-Author: Shu-Wha Lin – Department of Clinical Laboratory Science and Medical Biotechnology, National Taiwan University