PB0906 - Risk factors for venous thromboembolism after surgery for lung transplantation

Monday, June 24, 2024

13:45 – 14:45 ICT

Room: Exhibition Hall

Co-Author(s)

SP

Serena M. Passamonti

MD
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy
Milan, Lombardia, Italy

Presenting Author(s)

Paolo Bucciarelli

MD
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy
Milano, Lombardia, Italy

Co-Author(s)

EL

Elena Longhi

BSc
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Transplant Coordination Reference Center - Northern Italy Transplant Program (CRR/NITp)
Milan, Lombardia, Italy
LM

Letizia C. Morlacchi

MD
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Internal Medicine Dpt., Respiratory Unit and Cystic Fibrosis Center
Milan, Lombardia, Italy
PM

Paolo Mendogni

MD
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Thoracic Surgery and Lung Transplantation Unit
Milan, Lombardia, Italy
MG

Michela Grassi

BSc
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Transplant Coordination Reference Center - Northern Italy Transplant Program (CRR/NITp)
Milan, Lombardia, Italy
TD

Tullia De Feo

MD
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Transplant Coordination Reference Center - Northern Italy Transplant Program (CRR/NITp)
Milan, Lombardia, Italy
Flora Peyvandi, MD, PhD

Full Professor
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Università degli Studi di Milano, Department of Pathophysiology and Transplantation
Milan, Lombardia, Italy

Background: Venous thromboembolism (VTE), i.e., deep vein thrombosis (DVT) or pulmonary embolism (PE), may complicate lung transplantation, particularly DVT at the site of vascular access.

Aims: To evaluate the association between patients’ and donors’ characteristics and the risk of VTE in the post-operative period after lung transplantation.

Methods: Consecutive patients who underwent lung transplantation from February 2020 to February 2022 were included in this study. We considered all VTE episodes (lower or upper limb DVT or PE) occurred during hospitalization after surgery. In a multivariable logistic regression model, the following risk factors for VTE were considered: age of recipient, sex, body mass index (BMI), ABO blood group, use of Extra-Corporeal Membrane Oxygenation (ECMO), ex-vivo lung perfusion (EVLP) and Oto score. Odds ratios (OR) for VTE with their 95% confidence intervals (CI) were calculated.

Results: Sixty-six patients were included, 37 males (57%), median age (min-max) 49 years (16-69), median BMI (min-max) 22.8 Kg/m^2 (15.1-33.9). Non-O blood group was represented in 30 patients (46%) and ECMO was used in 44 patients (67%). A total of 19 VTE episodes were recorded (mostly DVT at the sites of venous access), of which 14 in the intensive care unit. Table 1 summarizes demographic and clinical characteristics of patients with and without VTE. The results of the logistic analysis are represented in Table 2. The risk factors mostly associated with VTE were ECMO use (OR 4.6 [95%CI:0.9-24.8]), Oto score (OR 2.9 [95%CI:0.6-14.0] for >4 vs ≤2) and non-O blood group (OR 1.7 [95%CI:0.5-6.1]).

Conclusion(s): ECMO use, Oto score >4 and non-O blood group were the most important risk factors for VTE during hospitalization after lung transplantation.