PB1472 - Clinical characteristics and risk factor analysis in a large cohort of Chinese patients with cerebral venous sinus thrombosis

Tuesday, June 25, 2024

13:45 – 14:45 ICT

Room: Exhibition Hall

Presenting Author(s)

Lei Li, Ph.D

Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai, Shanghai, China (People's Republic)

Co-Author(s)

Xi Wu, MD

Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai, Shanghai, China (People's Republic)
QD

Qiulan Ding

Professor
Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai, Shanghai, China (People's Republic)
XW

Xuefeng Wang

Professor
Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
Shanghai, Shanghai, China (People's Republic)

Background: Cerebral venous sinus thrombosis (CVST) is a rare and potentially fatal disease. The clinical features and risk factors of CVST in Chinese population have not been well characterized.

Aims: To analyze the clinical characteristics and risk factors of Chinese patients with CVST.

Methods: Clinical data of 118 CVST patients (62 males and 56 females) who visited the Thrombosis and Hemostasis Center of Ruijin Hospital were collected, including general condition, medical history and imaging characteristics, etc. The inherited and acquired thrombotic risk factors were screened based on phenotypic assays and next-generation sequencing, following Chi-square test and logistic regression analysis.

Results: Among the 118 CVST patients, 88.1% patients (104/118) firstly developed CVST before 45 years old. It revealed that 57.6% patients (68/118) only suffered CVST once, and 33.1% patients (39/118) experienced thrombotic events at least twice, while 37.3% patients (44/118) suffered multi⁃sites venous thromboembolism. 70.3% patients (83/118) carried at least one prothrombotic risk factor, including anticoagulant deficiencies, pregnancy/postpartum period, oral contraceptive use, antiphospholipid syndrome, and thrombocytosis, etc. Logistic regression analysis showed that both inherited risk factors (OR=21.643, 95% CI 9.455-49.544, P< 0.0001) and acquired risk factors (OR=10.836, 95% CI 4.306-27.270, P< 0.0001) were independent risk factors for the occurrence of CVST. Genetic risk factor (OR=2.270, 95% CI 1.021-5.048, P=0.044) was an independent risk factor for recurrent thrombosis in CVST patients.

Conclusion(s): In Chinese population, CVST is more common in middle-aged and young populations, with 70.3% patients carrying at least one thrombotic risk factor. Genetic risk factors are the main cause of CVST in China and the detectable rate is 53.3%, which is significantly higher than that (22%) reported abroad. The patients with genetic risk factors have a significantly increased risk of developing CVST or recurrent thrombosis. Identification of thrombotic risk factors, prevention, diagnosis and treatment should be carried out earlier for individuals with high-risk CVST.