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Henri M. Spronk, PhD

Professor of Biochemistry of Atherothrombosis
Maastricht University
Maastricht, Limburg, Netherlands

Dr Spronk is professor of Biochemistry of Atherothrombosis at Maastricht University and CEO of Coagulation Profile B.V. In his research Dr Spronk has shown that active coagulation enzymes, mainly thrombin and factor Xa, contribute to atherosclerosis development and progression, and that inhibiting these enzymes reduces plaque formation and can induce regression of atherosclerosis. Overall, hypercoagulability impacts the development and progression of atrial fibrillation, highlighting coagulation’s role in cardiovascular disease.

Dr Sponk's work includes documenting the ability of assays for plasma thrombin generation and active coagulation enzymes to predict thrombotic cardiovascular events or bleeding in animal models and large patient cohorts. Dr Spronk’s translational research involves creating and validating biomarker assays. His expertise in global haemostatic assays contributes to developing new diagnostic devices for routine measurement of activated platelets and point-of-care thrombin generation.
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The combined expertise of Dr Spronk in animal models and biomarkers for thrombotic cardiovascular disease led to founding Coagulation Profile BV, a Maastricht University-based company specialising in custom haemostatic assays, particularly thrombin generation, to support pre-clinical and clinical studies.

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