PB0427 - Regular versus extended thromboprophylaxis for venous thromboembolic disease: a single center, long-term, control-case study

Sunday, June 23, 2024

13:45 – 14:45 ICT

Room: Exhibition Hall

Presenting Author(s)

Marilyn G. Mendoza, MD

Medical resident on thrombosis and hemostasis
Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Mexico City, Distrito Federal, Mexico

Co-Author(s)

Adriana G. Garcia

Medical resident on thrombosis and hemostasis
Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Mexico City, Distrito Federal, Mexico
Stephania Sandoval Ocampo, Hematologist

Medical resident on thrombosis and hemostasis
Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Ciudad de méxico, Mexico City, Mexico
ML

María Graciela Leal Gutiérrez

Medical resident on thrombosis and hemostasis
Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Mexico City, Distrito Federal, Mexico
Emely J. Soriano, MD

Medical resident on thrombosis and hemostasis
Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Mexico City, Distrito Federal, Mexico
Andric Cuevas-Juárez, MD

Medical resident on thrombosis and hemostasis
Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Mexico city, Distrito Federal, Mexico
TM

Tania Marisol Martinez Garcia

Medical resident on thrombosis and hemostasis
Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Mexico City, Distrito Federal, Mexico
Margarita M. Thomas, MD

Medical Resident on Thrombosis and Hemostasis
1Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Mexico city, Distrito Federal, Mexico
Jose A. Aguilar

Medical resident on thrombosis and hemostasis
Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Ciudad de México, Distrito Federal, Mexico
AM

Abraham S Majluf

Heamatologist head of unidad de investigacion medica en trombosis hemostasia y aterogenesis
Instituto Mexicano del seguro social
Mexico City, Estado de México, Mexico

Background: Today, a growing percentage of patients with venous thromboembolic disease (VTD) require extended thromboprophylaxis (ET) instead of regular thromboprophylaxis (RT) because the rate of recurrence is unacceptably high after treatment is early stopped.

Aims: To analyze the long-term results comparing RT vs. ET in adult patients with a first episode of VTD

Methods: Since January 1st, 2003 up to December 31st, 2023, data of patients with objectively confirmed VTD refereed for diagnosis and treatment at the thrombosis unit were evaluated treated with ET and compared with patients treated in other departments in which the world-wide accepted periods of treatment were followed. From all patients, we gathered information regarding, demographics, risk factors, diagnosis, treatment indicated, and chronic complications. Patients with indication for anticoagulant life-long treatment were excluded.

Results: During the study period, 2,600 patients with VTD were attended at our unit and they were compared with 2,570 controls treated at other departments. Main characteristics of the patients are shown in Table 1. As shown, there were a few significant differences between the groups. Table 2 shows the most relevant data regarding the treatments indicated. As depicted in Table 2, in general, significant lower rates of thrombosis were found in the ET group in most of the variables analyzed. Moreover, we were unable to demonstrate significant differences in terms of bleeding in all variables analyzed.

Conclusion(s): In this prospective, comparative, long-term follow-up study of adult patients with a first VTD event, we found a positive impact on the efficacy on almost all variables without significantly increasing the bleeding episodes. Perhaps, these positive results with an ET regimen depend on both, a closer vigilance and the use of more standardized treatment criteria when the patients are attended in a thrombosis clinic