OC 49 - Regulation of FVIII

Moderator(s)

• 

  Alessia Dei Rossi

  PhD Student
  Dept. of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy
  Padova, Veneto, Italy
• 

  Peter Lenting, PhD

  Researcher
  INSERM U1176, Université Paris Saclay, Le Kremlin-Bicêtre, France
  Le Kremlin-Bicêtre, Ile-de-France, France

Presentations:

• 14:45 – 15:00 ICT

  Arginine Methylation by Protein arginine methyltransferase 1 (PRMT1) on ADAMTS13 Affects Its Secretion and Proteolytic Activity
  

  Presenting Author: Szumam Liu, PhD – University of Kansas Medical Center

  Co-Author: Xinyang Zhao – University of Kansas Medical Center

  Co-Author: Long Zheng, MD, PhD – University of Kansas Medical Center
• 15:00 – 15:15 ICT

  Identification of structural elements in factor V and factor VIII that determine their routes in the early secretory pathway
  

  Presenting Author: Bin Zhang, PhD – Cleveland Clinic Lerner Research Institute

  Co-Author: Yuan Zhang – Cleveland Clinic Lerner Research Institute
• 15:15 – 15:30 ICT

  Influence of coagulation proteases on cognitive function
  

  Presenting Author: Silke Zimmermann, MD PhD – Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital; Leipzig, Germany

  Co-Author: Akash Mathew – Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital; Leipzig, Germany

  Co-Author: Gyulten Mangova – Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital; Leipzig, Germany

  Co-Author: Berend Isermann, Prof. Dr. med. – Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig University, Leipzig, Germany
• 15:30 – 15:45 ICT

  An effective and safe strategy for anti-thrombosis therapy by monoclonal antibody blocking the interaction of FIXa with FVIIIa
  

  Presenting Author: Xuemei Fan, PhD – Shanghai Jiao Tong University School of Medicine

  Co-Author: Junling Liu, PhD – Shanghai Jiao Tong University School of Medicine

  Co-Author: Lin Zhang – Shanghai Jiao Tong University

  Co-Author: Xueqing Sun – Shanghai jiao tong university

  Co-Author: Yanhua Wang – Shanghai synvida bio.tech

  Co-Author: Yanjun Liu – Shanghai synvida biotech

  Co-Author: Qingqin Lai – Shanghai synvida biotech
• 15:45 – 16:00 ICT

  FVIII mutated with D519V/E665V/K1813A enhances coagulation potentials by high affinity for FIXa and stabilizing A2 domain
  

  Presenting Author: Yuto Nakajima, Md.PhD – Department of Pediatrics

  Co-Author: Akihisa Oda – Department of Pediatrics

  Co-Author: Keiji Nogami – Nara Medical University, Nara, Japan