OC 76 - Functional regulation of natural anticoagulants

Wednesday, June 26, 2024

10:15 – 11:30 ICT

Room:210 A-D

Moderator(s)

Steven Grover, PhD

Research Assistant Professor
Blood Research Center
Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill
Chapel Hill, North Carolina, United States
Anne Angelillo-Scherrer, MD

Head of Department
Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, Switzerland. Department for BioMedical Research, University of Bern, Murtenstrasse 40, CH-3010 Bern, Switzerland
Bern, Bern, Switzerland

Presentations:

10:15 – 10:30 ICT

Directed Evolution of An Antibody Specific for a Non-Active Site of Activated Protein C (APC) - Identification of Positions Within Each CDR for Selective Modulation of APC Pleiotropic Activities
Presenting Author: Derek S. Sim, PhD – Coagulant Therapeutics
Co-Author: Meenal Shukla – BioLegend/PerkinElmer
Co-Author: Cornell R. Mallari – Coagulant Therapeutics
Co-Author: Jose A. Fernández – The Scripps Research Institute
Co-Author: Xiao Xu – The Scripps Research Institute
Co-Author: Doug Schneider – Coagulant Therapeutics
Co-Author: Maxine Bauzon – Coagulant Therapeutics
Co-Author: Laurent O. Mosnier – Scripps Research
Co-Author: Terry W. Hermiston – Coagulant Therapeutics
10:30 – 10:45 ICT

Anti-proliferative, anti-angiogenic and anti-invasive effect of antithrombin in glioblastoma multiforme
Presenting Author: Julia Peñas Martínez, PhD Student – Department of Hematology and Medical Oncology, University General Hospital Morales Meseguer, Center of Hemodonation, University of Murcia, IMIB-Pascual Parrilla, 30003, Murcia, Spain
Co-Author: David Zaragoza Huesca, Degree in Biology and Master – Department of Hematology and Medical Oncology, University General Hospital Morales Meseguer, Center of Hemodonation, University of Murcia, IMIB-Pascual Parrilla, 30003, Murcia, Spain
Co-Author: Salvador Espin – Department of Hematology and Medical Oncology, University General Hospital Morales Meseguer, Center of Hemodonation, University of Murcia, IMIB-Pascual Parrilla, 30003, Murcia, Spain
Co-Author: Constantino Martínez – Department of Hematology and Medical Oncology, University General Hospital Morales Meseguer, Center of Hemodonation, University of Murcia, IMIB-Pascual Parrilla, 30003, Murcia, Spain
Co-Author: Rocío González-Conejero – Department of Hematology and Medical Oncology, University General Hospital Morales Meseguer, Center of Hemodonation, University of Murcia, IMIB-Pascual Parrilla, 30003, Murcia, Spain
Co-Author: María Luisa Lozano – Servicio de Hematología, Hospital General Universitario Morales Messeguer, Centro Regional de Hemodonación, Universidad de Murcia, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII
Co-Author: Vicente Vicente – Servicio de Hematología, Hospital General Universitario Morales Messeguer, Centro Regional de Hemodonación, Universidad de Murcia, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII
Co-Author: Irene Martínez Martínez – Servicio de Hematología, Hospital General Universitario Morales Messeguer, Centro Regional de Hemodonación, Universidad de Murcia, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII
10:45 – 11:00 ICT

Landscape of natural variants affecting the N-glycosylation of antithrombin: biological and clinical impact
Co-Author: Rosa Cifuentes-Riquelme – Servicio de Hematología, Hospital General Universitario Morales Messeguer, Centro Regional de Hemodonación, Universidad de Murcia, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII
Presenting Author: María Eugenia de la Morena-Barrio, PhD – Servicio de Hematología, Hospital General Universitario Morales Messeguer, Centro Regional de Hemodonación, Universidad de Murcia, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII
Co-Author: Kruijt Mirjam – Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden
Co-Author: Pedro Garrido-Rodríguez – Servicio de Hematología, Hospital General Universitario Morales Messeguer, Centro Regional de Hemodonación, Universidad de Murcia, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII
Co-Author: Juan José Rojo-Carrillo – Servicio de Hematología, Hospital General Universitario Morales Messeguer, Centro Regional de Hemodonación, Universidad de Murcia, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII
Co-Author: José Padilla – Servicio de Hematología, Hospital General Universitario Morales Messeguer, Centro Regional de Hemodonación, Universidad de Murcia, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII
Co-Author: Belén de la Morena-Barrio, PhD – Servicio de Hematología, Hospital General Universitario Morales Messeguer, Centro Regional de Hemodonación, Universidad de Murcia, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII
Co-Author: Carlos Bravo-Pérez – Servicio de Hematología, Hospital General Universitario Morales Messeguer, Centro Regional de Hemodonación, Universidad de Murcia, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII
Co-Author: Antonia Miñano – Servicio de Hematología, Hospital General Universitario Morales Messeguer, Centro Regional de Hemodonación, Universidad de Murcia, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII
Co-Author: Esther Navarro – Servicio de Hematología, Hospital General Universitario Morales Messeguer, Centro Regional de Hemodonación, Universidad de Murcia, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII
Co-Author: María Llamas-López, PhD-Student – Servicio de Hematología, Hospital General Universitario Morales Messeguer, Centro Regional de Hemodonación, Universidad de Murcia, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII
Co-Author: Vicente Vicente – Servicio de Hematología, Hospital General Universitario Morales Messeguer, Centro Regional de Hemodonación, Universidad de Murcia, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII
Co-Author: María Luisa Lozano – Servicio de Hematología, Hospital General Universitario Morales Messeguer, Centro Regional de Hemodonación, Universidad de Murcia, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII
Co-Author: Per Morten Sandset – Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
Co-Author: Pierre Morange, MD, PhD – Aix-Marseille University
Co-Author: L. Renee Ruhaak – Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden
Co-Author: Javier Corral – Servicio de Hematología, Hospital General Universitario Morales Messeguer, Centro Regional de Hemodonación, Universidad de Murcia, Universidad de Murcia, IMIB-Pascual Parrilla, CIBERER-ISCIII
11:00 – 11:15 ICT

Citrullination of TFPI impairs its natural anticoagulant activity towards factors Xa, VIIa and tissue factor, and reduces binding of its cofactor protein S.
Presenting Author: Bryan RC Bouwens, MSc – CARIM - department of biochemistry - Maastricht university
Co-Author: Stella Thomassen – Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University
Co-Author: Elke Magdeleyns – Maastricht University
Co-Author: Dennis Suylen – Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University
Co-Author: Tilman M. Hackeng, PhD – Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University
Co-Author: Rory R. Koenen – Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University
11:15 – 11:30 ICT

Protein S enhances the phagocytosis of phosphatidylserine-positive procoagulant erythrocyte ghosts in sickle cell disease
Presenting Author: Claire Auditeau, PharmD – Hémostase Inflammation Thrombose (HITh) UMR-S1176 INSERM Université Paris-Saclay Le Kremlin-Bicêtre France
Co-Author: Aurélie Fricot-Monsinjon – Université Paris Cité and Université des Antilles, Inserm, Biologie Tissulaire du Globule Rouge, Paris, France
Co-Author: Raphaël Gauthier – Université Paris Cité and Université des Antilles, Inserm, Biologie Tissulaire du Globule Rouge, Paris, France.
Co-Author: Zeynep Cacan – Université Paris Cité and Université des Antilles, Inserm, Biologie Tissulaire du Globule Rouge, Paris, France.
Co-Author: Alain Brisson – UMR-CBMN, CNRS-Université de Bordeaux-IPB, 33600 Pessac, France.
Co-Author: Céline Gounou – UMR-CBMN, CNRS-Université de Bordeaux-IPB, 33600 Pessac, France.
Co-Author: Laure Joseph – Department of Biotherapy, French National Sickle Cell Disease Referral Center, Hôpital Necker, Assistance-Publique Hôpitaux de Paris, Paris, France
Co-Author: Sandra Manceau – Department of Biotherapy, French National Sickle Cell Disease Referral Center, Hôpital Necker, Assistance-Publique Hôpitaux de Paris, Paris, France
Co-Author: Mariem Khamari – Hémostase, Inflammation, Thrombose (HITh), UMR-S1176, INSERM, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
Co-Author: Sophie moog – Hémostase, Inflammation, Thrombose (HITh), UMR-S1176, INSERM, Université Paris-Saclay, Le Kremlin-Bicêtre, France
Co-Author: Pierre Buffet – Université Paris Cité and Université des Antilles, Inserm, Biologie Tissulaire du Globule Rouge, Paris, France,
Co-Author: Delphine Borgel – Hémostase Inflammation Thrombose (HITh) UMR-S1176 INSERM Université Paris-Saclay Le Kremlin-Bicêtre France
Co-Author: François Saller – INSERM U1176, Université Paris Saclay, Le Kremlin-Bicêtre, France
Co-Author: Camille Roussel – Université Paris Cité and Université des Antilles, Inserm, Biologie Tissulaire du Globule Rouge, Paris, France