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Joseph R. Shaw, MD, MSc, FRCPC

Associate Scientist/Physician
The Ottawa Hospital

Joseph R. Shaw, MD MSc FRCPC is a hematologist and thrombosis medicine specialist in the Department of Medicine at The Ottawa Hospital. He is an Associate Scientist at the Ottawa Hospital Research Institute and an Assistant Professor in the Faculty of Medicine at the University of Ottawa. He completed his undergraduate studies in Biochemistry at McGill University, followed by his M.D., Internal Medicine and Hematology training at the University of Ottawa, as well as Royal College of Physicians and Surgeons AFC training in Adult Thrombosis Medicine through the Thrombosis Unit at The Ottawa Hospital. He also completed a Master of Science in Epidemiology through the University of Ottawa. His thesis dissertation was on the utility of thrombin generation assays towards measuring the anticoagulant effects of direct oral anticoagulants and anticoagulation reversal. Dr. Shaw’s research is focused on evaluating anticoagulation reversal strategies, as well as the perioperative management of anticoagulants. He is interested in studying the potential clinical applications of thrombin generation assays, including evaluating anticoagulant pharmacodynamics and the effects of reversal agents and hemostatic therapies.

He is currently the lead investigator for a prospective observational study (GAUGE) evaluating the effects of prothrombin complex concentrates on thrombin generation parameters in patients with direct Xa inhibitor-associated bleeding. Dr. James Douketis and Dr. Shaw are co-Principal Investigators of the PAUSE-2 randomized controlled trial, comparing PAUSE vs ASRA perioperative DOAC management for patients undergoing high-bleed-risk invasive procedures.

Dr. Shaw has presented his research at national and international conferences. His research on biomarker-enhanced VTE risk stratification in patients with cancer was awarded the Canadian Hematology Society’s John H. Crookston Award in 2019 and his publication on the perioperative management of anticoagulation among patients with cancer-associated VTE was recognized with the Journal of Thrombosis and Haemostasis’ Editors Award in 2020.

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