Khurrum Shahzad

PostDoc
University of Leipzig
Leipzig, Sachsen, Germany

Shahzad, Khurrum, Dr. University Hospital Leipzig.
Cardiovascular diseases (CVDs) affect the heart and blood vessels and are a leading cause of morbidity and mortality worldwide. They encompass a wide range of conditions including atherosclerosis, peripheral arterial disease, myocardial infarction (heart attack), and heart failure. Diabetic patients have a greater risk of developing CVD. Chronic kidney disease (CKD) is associated with a significantly increased risk of developing CVDs. Loss of coagulation regulators (thrombomodulin and activated protein C) have been repeatedly demonstrated CVDs and CKD. Thromboinflammation (interplay between the blood coagulation, and inflammatory responses) plays a significant role in the development and progression of various CVDs. Our work focuses on understanding the role of coagulation regulator and thromboinflammation in CVDs and CKD induced CVDs. Understanding the underlying mechanisms in CVDs will provide insights into potential therapeutic targets for the prevention and treatment of CVDs.

Presentation(s):

• PB0844 - Activated Protein C ameliorates diabetes induced atherosclerosis by sustaining efferocytosis

  Monday, June 24, 2024
  13:45 – 14:45 ICT

• PB1077 - Factor XII-uPAR interaction drives oxidative DNA damage and senescence in kidney tubular cells under hyperglycemic conditions

  Tuesday, June 25, 2024
  13:45 – 14:45 ICT

• OC 79.3 - Antiplatelet and anticoagulant (APAC) compound restricts thromboinflammation and maintains cardiac function following myocardial injury

  Wednesday, June 26, 2024
  10:45 – 11:00 ICT