Professor
University of Michigan Medical School
Ann Arbor, Michigan, United States
James H. Morrissey, Ph.D., is a Professor of Biological Chemistry and Internal Medicine at the University of Michigan Medical School in Ann Arbor, Michigan, USA. Beginning with the cloning of tissue factor in 1987, Dr. Morrissey's research has focused on biochemical mechanisms by which the blood clotting system is regulated, with a particular interest in understanding how the clotting cascade is triggered and how protein-membrane interactions regulate blood clotting reactions. In 2006, his laboratory reported the discovery that inorganic polyphosphate, which is released from activated human platelets, is a potent modulator of blood clotting and inflammation, and can help explain the otherwise puzzling role of factor XI in hemostasis. More recently his lab has reported that platelet polyphosphate is a signaling molecule with potential roles in wound healing and fibrosis. Work from his lab has led to spin-offs with potential clinical applications, including new diagnostic assays. His lab is also working on novel hemostatic agents for treating bleeding, and on anti-inflammatory/anti-thrombotic agents with reduced bleeding side effects relative to conventional anticoagulant drugs.
SOA 01.4 - How coagulation factor structure shapes function
Sunday, June 23, 2024
08:00 – 09:15 ICT