PB0778 - Effects of Intravenous Iron Infusion on Platelet Function in Orthopedic Trauma Patients

Monday, June 24, 2024

13:45 – 14:45 ICT

Room: Exhibition Hall

Presenting Author(s)

Chih-Jen Yang, MD

PhD student
Oregon Health & Science University
King City, Oregon, United States

Co-Author(s)

VD

Victoria Duke

PhD student
Oregon Health & Science University
Portland, Oregon, United States
MG

Michaela Geffert

undergraduate intern
Oregon Health & Science University
Portland, Oregon, United States
DP

Danielle Peterson

Resident physician
Oregon Health & Science University
Portland, Oregon, United States
NM

Natasha McKibben

Resident physician
Oregon Health & Science University
Portland, Oregon, United States
CH

Catherine Hutchison

Resident physician
Oregon Health & Science University
Portland, Oregon, United States
NW

Nick Willett

Associate Professor
University of Oregon
Eugene, Oregon, United States
JS

Joseph Shatzel

Associate Professor
Oregon Health & Science University
Portlan, Oregon, United States
ZW

Zachary Working

Associate Professor
Oregon Health & Science University
Portland, Oregon, United States
JA

Joe Aslan, PhD

Oregon Health & Science University, United States

Background: Orthopedic trauma patients are often anemic. We recently demonstrated that intravenous iron therapy restores platelet counts and platelet secretory responses in premenopausal women with iron deficiency. However, the impact of iron repletion on platelet function in orthopedic trauma patients remains unclear.

Aims: Here, we aim to test the hypothesis that intravenous iron improves platelet count and function in patients with orthopedic trauma.

Methods: In an ongoing single-center, double-blind, randomized controlled trial, we evaluated a single dose infusion of low-molecular-weight iron dextran (1000 mg) as compared with a placebo in adult patients admitted for lower extremity or pelvis operative fracture care with a hemoglobin of 7-11 g/dL. Pre- and 3-month post-infusion blood samples were collected from the cohort of 20 patients to analyze the effect of intravenous iron on hematologic parameters and platelet function with flow cytometry and platelet-associated cytokine levels.

Results: Platelet count and mean platelet volume did not significantly differ between the iron-treated and control groups. However, iron repletion decreased baseline levels of P-selectin on circulating platelets and enhanced platelet secretory responses to platelet agonists. In addition, the iron-treated group exhibited a lower level of soluble CD40L, suggesting diminished inflammatory responses.

Conclusion(s): Iron repletion may have a moderate but significant effect on platelet function and restore platelet reactivity in anemic patients with orthopedic trauma.