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Poster Networking

Acquired and Critical Care Bleeding

PB1025 - The benign prostate enlargement correlates with the weakening of whole blood clot formation

Tuesday, June 25, 2024
13:45 – 14:45 ICT
Room: Exhibition Hall

    Co-Author(s)

  • AF

    Aleksandra Filkova

    Researcher, Associate Professor
    Center for Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences
    Moscow, Moskva, Russia

    • Co-Author(s)

  • AI

    Anastasia Ignatova

    Research associate
    Dmitry Rogachev National Medical Research Centеr of Pediatric Hematology, Oncology and Immunology
    Moscow, Moskva, Russia

    • Presenting Author(s)

  • Elena A. Seregina, PhD

    Leading Researcher
    Dmitry Rogachev National Medical Research Centеr of Pediatric Hematology, Oncology and Immunology
    Moscow, Moskva, Russia

    • Co-Author(s)

  • AT

    Anastasia Tarakanova

    PhD Candidate
    Center for Theoretical Problems of Physico-Chemical Pharmacology RAS, Moscow, Russia
    Moscow, Moskva, Russia

  • AM

    Alexey Martyanov

    Researcher
    Dmitry Rogachev National Medical Research Centеr of Pediatric Hematology, Oncology and Immunology
    Chapel Hill, North Carolina, United States

  • EP

    Evgeniya A. Ponomarenko

    Junior researcher, PhD
    Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
    Moscow, Moskva, Russia

  • AK

    Anna Korneichuk

    Researcher
    Center for Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences
    Moscow, Moskva, Russia

  • Alexander Poletaev

    Head of the Laboratory of Clinical Hemostasis
    Dmitry Rogachev National Medical Research Centеr of Pediatric Hematology, Oncology and Immunology
    Moscow, Moskva, Russia

  • EK

    Ekaterina M. Koltsova

    Leading researcher, PhD
    Dmitry Rogachev National Medical Research Center Of Pediatric Hematology, Oncology and Immunology
    Moskva, Moskva, Russia

  • AB

    Anna N. Balandina

    Senior researcher, PhD
    Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
    Moscow, Moskva, Russia

  • AS

    Anastasia N. Sveshnikova

    Head of Laboratory
    Dmitry Rogachev National Medical Research Center Of Pediatric Hematology, Oncology and Immunology, Moscow, Russia
    Moscow, Moskva, Russia

  • SB

    Sergey Belomyttsev

    Medical doctor
    Moscow City Clinical Hospital No.64
    Moscow, Moskva, Russia

  • MP

    Mikhail Panteleev

    Director
    Center for Theoretical Problems of Physico-Сhemical Pharmacology
    Moscow, Moskva, Russia

Background: It has been widely investigated that malignant tumors have a huge impact on hemostasis. More than 70% of men over 70 years old face the enlargement of the prostate gland - benign prostatic hyperplasia (BPH). Despite its high prevalence, there is a lack of knowledge regarding the effects of BPH on hemostatic parameters.

Aims: To investigate the correlation between preoperative prostate adenoma volume in patients undergoing transurethral resection of the prostate (TURP) and their hemostatic parameters.

Methods: 21 male patients (55-87 y.o.; mean: 72 y.o.) underwent TURP, with BPH (30-130 cm^3; mean: 74 cm^3). A group of 50 healthy donors (23-85 y.o.; mean: 23 y.o.) and a group of 7 healthy donors (65-75y.o.; mean: 73 y.o.). Blood was collected into citrate tubes, and the parameters of the hemostatic system were assessed 2 hours before surgery. Platelets were assessed with light-transmission aggregometry and flow cytometry. Coagulation was assessed by thromboelastography and Quick prothrombin test. Informed consent was obtained, and the institutional ethical committee (09/07/20 Vinogradov Clinical Hospital) approved the study.

Results: Patients showed reduced platelet aggregation in response to ADP and decreased expression level of integrin αIIbβ3 upon stimulation (ADP, PAR1-AP and collagen-related peptide, CRP) compared with both groups of healthy donors. The release of calcium into the cytoplasm of platelets after activation by CRP was reduced in patients. The values of Quick prothrombin test were reduced compared to healthy groups.
Thromboelastography parameters showed a correlation with the volume of BPH: the larger benign prostate diagnosed in a patient, the greater the K time and the less the alpha value.

Conclusion(s): BPH correlated with hemostasis, with increased coagulation and reduced platelet functionality. The size of the benign prostate negatively correlated with the degree of activation of the hemostatic system: whole blood clot formation time is elevated, and the rate of fibrin generation is reduced.