OC 28 - Platelet biology discovery

Moderator(s)

• 

  Swati Sharma

  Post Doc
  Blood Research Center, UNC
  Chapel Hill, North Carolina, United States
• 

  Renhao Li, PhD

  Professor
  First Affiliated Hospital, Zhejiang University School of Medicine
  Hangzhou, Zhejiang, China (People's Republic)

Presentations:

• 14:45 – 15:00 ICT

  Myosin light chain 6 (Myl6) interacts with kindlin-3 and is required to support integrin αIIbβ3 activation in platelets
  

  Presenting Author: Zhen Xu, PhD – Versiti Blood Research Institute

  Co-Author: Ying Zhou – Research Technologist

  Co-Author: Hongyin Yu – Versiti Blood Research Institute

  Co-Author: Xue Chen – Shanghai Jiaotong University

  Co-Author: Yan-Qing Ma – Versiti Blood Research Institute
• 15:00 – 15:15 ICT

  Platelet β1 and β3 integrins are essential for hemostasis, arterial thrombosis and tumor metastasis
  

  Presenting Author: Emily Janus-Bell, PhD – Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, F-67065 Strasbourg, France

  Co-Author: Cristina Liboni – INSERM UMR_S1109, Tumor Biomechanics Lab, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), CNRS, SNC5055, Strasbourg, France

  Co-Author: Alexandra Yakusheva – Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, F-67065 Strasbourg, France

  Co-Author: Vincent Mittelheisser – INSERM UMR_S1109, Tumor Biomechanics Lab, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), CNRS, SNC5055, Strasbourg, France

  Co-Author: Louis Bochler – INSERM UMR_S1109, Tumor Biomechanics Lab, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), CNRS, SNC5055, Strasbourg, France

  Co-Author: Clarisse Mouriaux – Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, F-67065 Strasbourg, France

  Co-Author: Catherine Bourdon – Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, F-67065 Strasbourg, France

  Co-Author: Maria Garcia-Leon – INSERM UMR_S1109, Tumor Biomechanics Lab, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), CNRS, SNC5055, Strasbourg, France

  Co-Author: Vincent Hyenne – INSERM UMR_S1109, Tumor Biomechanics Lab, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), CNRS, SNC5055, Strasbourg, France

  Co-Author: Olivier Lefebvre – INSERM UMR_S1109, Tumor Biomechanics Lab, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), CNRS, SNC5055, Strasbourg, France

  Co-Author: Jacky Goetz – INSERM UMR_S1109, Tumor Biomechanics Lab, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), CNRS, SNC5055, Strasbourg, France

  Co-Author: Pierre H. Mangin, PhD – University of Strasbourg, INSERM, EFS Grand-Est, BPPS UMR-S1255, FMTS, Strasbourg, France
• 15:15 – 15:30 ICT

  Direct binding of Lyn to GPIb beta transmembrane/cytoplasmic domain transmits platelet activation signal and regulates GPIb alpha–VWF binding
  

  Presenting Author: Yaping Zhang, MS,MBA – University of Illinois at Chicago

  Co-Author: Ying Liang – University of illinois at Chicago

  Co-Author: Amir Hossein Kazemipour Ashkezari – Georgia Institute of Technology

  Co-Author: Cheng Zhu – Georgia Institute of Technology

  Co-Author: Xiaoping Du – University of illinois at Chicago
• 15:30 – 15:45 ICT

  Hippo pathway effector TAZ negatively regulates platelet activation and thrombosis by inhibiting MEK-ERK-cPLA2 pathway
  

  Presenting Author: Xiaowen Wu, MA – School of Pharmacy, Tianjin Medical University, Tianjin, China

  Co-Author: Guanxing Pan – Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University

  Co-Author: Yulong Zhang, MD – School of Pharmacy, Tianjin Medical University, Tianjin, China

  Co-Author: Zhiling Zhang – Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

  Co-Author: Yifan Guo – Department of Cardiology, Tianjin Medical University General Hospital

  Co-Author: Li Li – Intensive Care Unit, The Second Hospital of Tianjin Medical University,

  Co-Author: Qingyuan Yang – School of Pharmacy, Tianjin Medical University

  Co-Author: Meng Du – School of Pharmacy, Tianjin Medical University

  Co-Author: Qian Liu – School of Pharmacy, Tianjin Medical University

  Co-Author: Yixian Wang – School of Pharmacy, Tianjin Medical University

  Co-Author: Meina Jin – School of Pharmacy, Tianjin Medical University

  Co-Author: Zhiqiang Zhao – Departement of Cardiology,The Second Hospital of Tianjin Medical University

  Co-Author: Fa-xing Yu – Institutes of Biomedical Sciences, Fudan University

  Co-Author: Shaopeng Xu – Department of Cardiology, Tianjin Medical University General Hospital

  Co-Author: Qing Yang – Department of Cardiology, Tianjin Medical University General Hospital

  Co-Author: Bing Chen – Intensive Care Unit,The Second Hospital of Tianjin Medical University

  Co-Author: Xiongwen Chen – School of Pharmacy, Tianjin Medical University

  Co-Author: Zhongren Ding – School of Pharmacy, Tianjin Medical University; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences , Fudan University; Department of Geriatrics, The Second Hospital of Tianjin Medical University
• 15:45 – 16:00 ICT

  A novel experimental model of stable thrombosis: the anti-GPVI agent, glenzocimab, efficiently destabilizes an established thrombus
  

  Presenting Author: Charlotte E. Fauth, Master student – EFS Alsace Grand Est, UMRS_1255

  Co-Author: Kim Ashley JOUFFROY, DVM – EFS-Alsace

  Co-Author: Alexandra Yakusheva – Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS, F-67065 Strasbourg, France

  Co-Author: Andréa Thevenot – Etablissement Français du Sang Grand-Est UMRS-1255

  Co-Author: Martine Jandrot-Perrus, MD., PhD. – Laboratory for Vascular Translational Science, UMR_S1148 INSERM, University Paris Cité, Hôpital Bichat, Paris, France

  Co-Author: Pierre H. Mangin, PhD – University of Strasbourg, INSERM, EFS Grand-Est, BPPS UMR-S1255, FMTS, Strasbourg, France