OC 15 - von Willebrand factor & ADAMST13 biology

Moderator(s)

• 

  Long Zheng, MD, PhD

  Professor and Chair
  University of Kansas Medical Center
  Kansas City, Kansas, United States
• 

  Ferdows Atiq, MD, MSc, PhD

  Senior Research Fellow
  Royal College of Surgeons in Ireland
  Dublin, Dublin, Ireland

Presentations:

• 09:30 – 09:45 ICT

  Crystal structure of the von Willebrand factor A1 domain in complex with a novel inhibitory nanobody
  

  Presenting Author: Jonas Emsley, PhD – University of Nottingham

  Co-Author: Renhao Li, PhD – First Affiliated Hospital, Zhejiang University School of Medicine
• 09:45 – 10:00 ICT

  N-glycans located in the VWF-A2 domain regulate A1-domain mediated clearance through macrophage LRP1 and SR-A1 receptors
  

  Presenting Author: Alain Chion, PhD – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

  Co-Author: Sonia Aguila, PhD – Centro Regional de Hemodonación, IMIB-Pascual Parrilla, UCAM

  Co-Author: Judicael Fazavana – Royal College of Surgeons In Ireland

  Co-Author: Ciara Byrne, PhD – RCSI Dublin

  Co-Author: Patricia Lopes, MSc – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland

  Co-Author: Tom McKinnon – Imperial College London

  Co-Author: James S. O'Donnell – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
• 10:00 – 10:15 ICT

  Terminal sialylation of commercial rVWF concentrate is responsible for attenuated macrophage-mediated clearance via the MGL receptor.
  

  Presenting Author: Ciara Byrne, PhD – RCSI Dublin

  Co-Author: Soracha Ward – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

  Co-Author: Alan B. Moran – Ludger Ltd

  Co-Author: Daniel Spencer – Ludger Ltd

  Co-Author: Richard Gardner – Ludger Ltd

  Co-Author: Marco Monopoli – RCSI Dublin

  Co-Author: Patricia Lopes – RCSI Dublin

  Co-Author: Alain Chion, PhD – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

  Co-Author: Jamie O'Sullivan – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

  Co-Author: Ross Baker, MB BS BMedSc FRACP, FRCPA – Western Australia Centre for Thrombosis and Haemostasis, Perth Blood Institute, Murdoch University, Perth, Australia

  Co-Author: Peter L. Turecek, PhD, PharmD – Baxalta Innovations GmbH, a Takeda company, Vienna, Austria

  Co-Author: James S. O'Donnell – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
• 10:15 – 10:30 ICT

  A balance of von Willebrand factor multimer size and platelet activation in a high shear mouse model to modulate hemostasis
  

  Co-Author: Alice Liu – Washington University in St. Louis

  Co-Author: Katrina Ashworth – Washington University Saint Louis

  Co-Author: NIna Lasky – Washington University Saint Louis

  Co-Author: Jorge Di Paola, MD – Washington University School of Medicine

  Presenting Author: David Bark, Jr., PhD – Washington University in St. Louis
• 10:30 – 10:45 ICT

  The conformational opening of ADAMTS13 does not necessarily indicate preactivation of its metalloprotease domain.
  

  Presenting Author: Quintijn Bonnez, MA – Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium

  Co-Author: Magdalena Gierula – Department of Immunology and Inflammation, Imperial College London, London, United Kingdom

  Co-Author: Inge Pareyn – Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium

  Co-Author: Febe Boudry – Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium

  Co-Author: Claudia Tersteeg – Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium

  Co-Author: Simon F. De Meyer – Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium

  Co-Author: James T.B. Crawley – Department of Immunology and Inflammation, Imperial College London, London, United Kingdom

  Co-Author: Karen Vanhoorelbeke – Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium