Post-Doctoral Fellow
Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Dublin, Dublin, Ireland
Dr Alain Chion, PhD. Royal College of Surgeons in Ireland
I am primarily interested in protein structure/function studies & pathological mechanisms. My previous works were on von Willebrand Factor (VWF) cleavage by ADAMTS-13. The cleavage site is buried within A2 domain & ADAMTS-13 can not bind to VWF-A2 without shear. Instead, ADAMTS-13 docks in VWF D4 region. I have also worked on the roles of calcium in ADAMTS-13 cleavage activity. Calcium ions are essential for shaping substrate-loop in the metalloprotease domain.
My latest works are on the clearance of VWF by scavenger receptors & lectins. Macrophage scavenger receptor LRP1 has a critical role in removing VWF from circulation. Interaction between VWF & LRP1 requires shear & change of conformation. A critical binding site for LRP1 is hidden on the surface of A1, a patch of 4 Lys that is at the edge of the binding site of two described aptamers. By binding to A1, the aptamer BT200 prevents VWF interacting with LRP1 & consequently extends VWF half-life in blood.
Sunday, June 23, 2024
09:45 – 10:00 ICT
Sunday, June 23, 2024
10:00 – 10:15 ICT
OC 58.1 - The molecular basis underpinning the enhanced clearance of VWF Vicenza (R1205H)
Tuesday, June 25, 2024
09:30 – 09:45 ICT