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David-Alexandre Trégouët

Senior Investigator
Bordeaux Population Health research Center, Inserm U1219, Bordeaux University
Bordeaux, Aquitaine, France

Holder of a PhD in Public Health (1999), with strong emphasis on statistical genetics, my research
career started with the development of statistical methods to analyze family data as well as genetic
polymorphisms in the context of candidate association studies. I then turned to the development
and the application of statistical/bioinformatics tools for the analysis of high-throughput
microarray and next generation sequencing data. In parallel to these methodological developments,
I am participating in the design and data analysis of several epidemiological studies aiming at
identifying molecular determinants of cardiometabolic and vascular diseases, my favorite disease
being venous thrombosis (VT). I am joint coordinator of the French EOVT, FARIVE, MARTHA,
MARFAST and PILGRIM studies, and joint convener of the International Network of Venous
Thrombosis (INVENT) consortium, aimed at identifying genetic factors for VT. Within the F-
CRIN supported INNVOTE network that assembled all French clinician working in the field of
VTE, I am responsible of the research programs on VT genomics.
In more recent years, my interests have extended to molecular epidemiology integrating epigenetics
marks, microRNA and proteomic profiling in order to develop a research program on precision
medicine in thrombotic disorders as well as on the identification and characterization of upstream
Open Reading Frames contributing to rare and common forms of cardiovascular diseases

Presentation(s):