PB1217 - Erectile dysfunction is related to quality of life, but not to risk factors for cardiovascular diseases, among adult men with hemophilia

Tuesday, June 25, 2024

13:45 – 14:45 ICT

Room: Exhibition Hall

Presenting Author(s)

Ricardo Mesquita Camelo, MD, MBA, MSc, PhD, PostD

Professor
Department of Internal Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil
Belo Horizonte, Minas Gerais, Brazil

Co-Author(s)

AR

Andre Vinícius Rocha

Urologist
Hospital Manoel Gonçalves de Sousa Moreira
Itaúna, Minas Gerais, Brazil
ER

Eduardo Remor

Professor of Psychology
Institute of Psychology, Social Work, Health, and Human Communication, Universidade Federal do Rio Grande do Sul (UFRGS)
Porto Alegre, Rio Grande do Sul, Brazil
BD

Bruna Pontes Duarte

Hematologist
Fundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE)
Recife, Pernambuco, Brazil
MM

Marilia Carolina Braga Moura

Hematologist
Fundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE)
Recife, Pernambuco, Brazil
NC

Neuza Cavalcanti Moraes Costa

Hematology Nurse
Fundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE)
Recife, Pernambuco, Brazil
IC

Iris Maciel Costa

Hematology Nurse
Fundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE)
Recife, Pernambuco, Brazil
AV

Ana Maria Vanderlei

Hematologist
Fundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE)
Recife, Pernambuco, Brazil
TG

Tania Maria Rocha Guimaraes

Hematology Nurse
Fundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE)
Recife, Pernambuco, Brazil

Background: Erectile dysfunction (ED) is a multifactorial disease related to psychosocial determinants and cardiovascular disease (CVD). Since adults with hemophilia (AwH) may have impaired psychosocial functioning due to the disease and have a high risk of developing CVD, we assumed ED might be prevalent among them.

Aims: We evaluated perceived ED using a validated self-reported questionnaire in AwH participating in a cross-sectional study to describe CVD and CVD risk factors (HemoCardio Study).

Methods: Male AwH aged ≥ 30 years attending a Northeastern Brazilian Hemophilia Treatment Center were invited. Demographic and clinical/therapeutic hemophilia data were collected from medical files. Clinical/therapeutic data about CVD and CVD risk factors were obtained by interview, physical examination, and laboratory tests. Perceived ED was evaluated by the International Index of Erectile Function-Erectile Function Domain (IIEF-6) instrument. Quality of life (QoL) was evaluated by HemoLatin-QoL and EQ-5D. Well-being was evaluated by the Hemophilia Well-Being Index (HWBI). For all questionnaires, higher scores meant better outcomes.

Results: A total of 84 AwH was included in the main study. Of the 52 AwH who responded to the IIEF-6, the median age was 42.0 years (interquartile range [IQR] 36.0-51.8), 43 (83%) had hemophilia A, and 25 (48%) were severe. The median IIFE-6 was 29.0 (IQR 25.3-30.0) and 13 (25%) perceived ED. Perceived ED was associated with severe hemophilia (p=0.025), lower HemoLatin-QoL total score (p=0.010), and lower EQ-5D index (p=0.038), but fairly associated with the use of anti-hypertensive (p=0.043) and antidiabetic (p=0.049). HWBI did not differ between AwH who perceived or did not ED. IIEF-6 had a positive correlation with the emotional functioning domain of the HemoLatin-QoL (n=47, ρ=0.313, p=0.032), but not with HemoLatin-QoL total score, EQ-5D index, or HWBI.

Conclusion(s): We could not find associations between CVD or CVD risk factors and perceived ED among AwH. However, perceived ED correlated with QoL.