PB0372 - Significance of omentin-1 and visfatin in platelet activation and blood coagulation in patients with venous thromboembolism

Background: Proteins secreted from adipocytes - so-called adipocytokines - influence metabolic and vascular function. Omentin-1, a novel adipokine expressed in visceral adipose tissue, is negatively correlated with insulin resistance and obesity.

Aims: The purpose of this study was to investigate the potential roles of omentin-1 and visfatin in patients who developed venous thromboembolism (VTE) and to evaluate the correlation between the adipocytokines and markers of coagulative activation.

Methods: We consecutively evaluated 186 patients with validated VTE. Baseline concentrations of сirculating levels of omentin-1, visfatin, von Willebrand Factor (VWF), factor (F)VIIa, prothrombin fragment 1 + 2 (F1+2), 11-dehydro-thromboxane B2 (TXM), activated protein C, and soluble thrombomodulin (TM) were determined by enzyme-linked immunosorbent assay (ELISA).

Results: VTE patients had significantly higher levels of visfatin, VWF, FVIIa, F1+2 compared with healthy men. Likewise, both TXM and prothrombin F1+2 levels were higher in VTE patients (P < 0.05). By contrast, omentin-1, anticoagulant markers, such as activated protein C, and TM were depressed in VTE patients (P < 0.05). Plasma levels of omentin-1 and visfatin correlated with TXM and prothrombin F1+2. Plasma levels of both adipokines have shown an correlation with markers of anticoagulation such as activated protein C and soluble thrombomodulin. A multiple linear regression analysis, performed to quantify further the relationship between omentin-1 and visfatin levels and the above-mentioned variables as well as the inflammatory marker C-reactive protein (CRP) and including age, body mass index, waist-hip ratio and lipid parameters as potential confounders, revealed that only FVIIa and VWF were independently related to omentin-1 levels as well as VWF to visfatin level.

Conclusion(s): Decreased levels of omentin-1 and increased concentrations of visfatin were associated with VTE. These results suggest that omentin-1 and visfatin levels may be novel biochemical risk factors for VTE, promoting to procoaculant reactions.