PB1388 - High Neutrofil Count and Thrombocytopenia Are Associated with High Mortality in COVID 19 Patients

Background: The pathology mechanism of COVID-19 is thromboinflammation.There is activation of coagulation cascade by immune response to viral invasion. The activation of platelets and neutrophils result in vascular thrombosis. The deterioration of COVID-19 patients are because of thrombosis in pulmonary vascular. This will result in respiratory failure and death in COVID-19 patients. The scope of this study is COVID-19 patients who were admitted to Dr. Cipto Mangunkusumo National Referral Hospital in 2021. The previous studies have shown the correlation of platelet count with mortality, with different platelet cut-off between studies. There are meta-analysis studies about the association of neutrophilia with COVID-19 mortality albeit with limited case numbers.

Aims: To know the association of neutrophil count and platelet count with mortality in COVID-19 patients

Methods: The study design is cross-sectional with bivariate analysis using Chi-square analysis or Fisher test.

Results: There was 1000 subjects, consisting of 488 males and 512 females, 66,2% of whom were under 60 years old. There was 23,8% of COVID-19 patients with a platelet count below 144.000 who died compare to 14.3% of COVID-19 patients with a platelet count above 144.000 (P < 0.05). There were 40.4% of COVID-19 patient with a neutrophil count above 10.000 who died compare to 11.4% of COVID-19 patients with a neutrophil count below 10.000 (P 0.000)

Conclusion(s): Neutrophilia and a low platelet count are associated with higher mortality in COVID-19 patients