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Poster Networking

Women's Hemostasis and Thrombosis

Session: Obstetric hemorrhage and anemia: data from MINNIE registry
-Prospective study on feto-maternal outcoMe In aNemIc womEn-

PB0465 - Obstetric hemorrhage and anemia: data from MINNIE registry -Prospective study on feto-maternal outcoMe In aNemIc womEn-

Sunday, June 23, 2024
13:45 – 14:45 ICT
Room: Exhibition Hall
Background: Pregnancy-related mortality worldwide is mainly due to hemorrhage and venous thromboembolism (VTE).

Aims: To estimate whether and to what extent antenatal hemoglobin is a risk factor for adverse obstetric outcomes.

Methods: MINNIE is a prospective observational study, that recruited consecutive pregnant women referred for delivery to three Ob/Gyn departments of tertiary care hospitals from January 2022 to March 2023. We collected maternal clinical and laboratory data along with feto-maternal outcomes. Maternal and fetal outcomes were also collected: maternal or fetal/neonatal death, venous thromboembolism, antepartum and peripartum (collectively defined as obstetric) hemorrhage, preterm deliveries, and neonatal birth-weight. Anemia was categorized into no anemia (hemoglobin 11 g/dL or greater), mild (9-10.9 g/dL), moderate (7-8.9 g/dL), severe (less than 7 g/dL).

Results: We recruited 2176 women, whose characteristics are shown in table 1. Among them, one deep venous thrombosis was recorded and 30 obstetric hemorrhage (13.4 per 1,000). Table 2 shows outcomes and hemostatic therapies according to the occurrence of hemorrhage. Preterm delivery (before the end of 37 weeks) was significantly associated with maternal hemorrhage. As for anemia, 371 (17.0) had mild, 21 (1.0%) moderate and 4 (0.2%) severe anemia, respectively, with no observed difference in rates of preterm and cesarean deliveries between anemic and nonanemic patients. The intrapartum-postpartum blood transfusion rate was 2.6 per 1,000. Moderate and severe anemia were significantly associated with lower neonatal birth weight (p=0.026) but not intrauterine fetal demise or neonatal death.

Conclusion(s): In non-selected pregnancies, obstetric hemorrhage is associated with preterm delivery and lower birth weight, without any significant impact on intrauterine or neonatal death.