PB1456 - Epidemiology and Risk Factors of Cancer associated thrombosis among Asian population - A single centre experience in Northern Sarawak, Malaysia

Background: Cancer-associated thrombosis (CAT) is a leading cause of mortality among the cancer patients. Incidences of CAT varied widely between studies due to the differences in disease biology, patient-related risk factors and cancer-directed therapy.

Aims: To determine the incidence, clinical and cancer-related risk factors of CAT in Northern Sarawak, Malaysia.

Methods: All oncological and hematological patients aged 15 years old and above diagnosed between 2021 and 2023 in Hospital Miri, Sarawak were included. Demographic data, clinical and laboratory data were tabulated to the designated case report form. All statistical analyses were performed using Stata, version 15.0; StataCorp and SPSS, version 23; IBM Corp software packages. Conditional logistics regression was performed to assess the CAT risk factors.

Results: 472 patients diagnosed with oncological (n=321,68%) and hematological cancer (n=151, 32%) with a mean age of 55 (15-85) were included. The male to female ratio was 1:1. Majority were Native (n=220, 46.6%) followed by Chinese (n=132, 28.6%) and Malay (n=107, 22.7%). Breast (n=94, 19.9%) and colorectal cancer (n=92, 19.5%) were the predominant cancer. 33 of them (7%) with median age of 59 and body mass index (BMI) of 21.4kg/m2 have CAT. Majority have deep vein thrombosis (n=15, 45.4%) and pulmonary embolism (n=11, 33.3%). Median hemoglobin, white blood cells (WBC) and platelets were 10.5g/dL, 7.81X10^9/L and 271x10^9/L respectively. 22 have passed away with median overall survival of 11 months (range 0-35). We demonstrated gender, race, BMI, presenting hemoglobin, WBC and platelet were not statistically associated with thrombosis among cancer patients.

Conclusion(s): The incidence of CAT here was 7% which was comparable with that in Western population. However, we could not demonstrate any statistically significant risk factors of CAT likely due to small sample size. In view of the lacking data of CAT among Asian population, more studies were crucial in enhancing our understanding of CAT in Asian countries.