PB0614 - Venous thromboembolism in paediatric patients: a monocentric, observational, and retrospective study in the years of the SARS-CoV-2 pandemic.

Monday, June 24, 2024

13:45 – 14:45 ICT

Room: Exhibition Hall

Co-Author(s)

GT

Gloria Tacchella

Doctor
Department of Medicine, University of Verona, Italy
Verona, Veneto, Italy
GS

Grazia Sidoti

Doctor
Maternal and Child Department, Pediatric Unit C, Azienda Ospedaliera Universitaria Integrata of Verona, Italy
Verona, Veneto, Italy
SM

Sara Moruzzi

Doctor
Department of Medicine, University of Verona, Italy
Verona, Veneto, Italy
Fp

Francesca pizzolo

Professor
Department of Medicine, University of Verona, Italy
Verona, Veneto, Italy
EB

Elisa Bonetti

Doctor
Paediatric Hematology-Oncology, Women's and Children's Hospital, Azienda Ospedaliera Universitaria Integrata of Verona, Italy
Verona, Veneto, Italy
RB

Renzo Beghini

Professor
Maternal and Child Department, Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Integrata of Verona, Italy
Verona, Veneto, Italy
PB

Paolo Biban

Professor
Maternal and Child Department, Pediatric Intensive Care Unit, Azienda Ospedaliera Universitaria Integrata of Verona, Italy
Verona, Veneto, Italy
SC

Simone Cesaro

Professor
Paediatric Hematology-Oncology, Women's and Children's Hospital, Azienda Ospedaliera Universitaria Integrata of Verona, Italy
Verona, Veneto, Italy
GP

Giorgio Piacentini

Professor
Department of Surgical Sciences, Dentistry, Ginecology and Pediatrics, Pediatric Clinic, University of Verona, Italy
Verona, Veneto, Italy
SF

Simonetta Friso

Professor
Department of Medicine, University of Verona, Italy
Verona, Veneto, Italy

Presenting Author(s)

Nicola Martinelli, MD, PhD

Associate Professor of Internal Medicine
Department of Medicine, University of Verona, Italy
Verona, Veneto, Italy

Background: Venous thromboembolism (VTE) is rare in children, although VTE is increasingly recognized as a complication of hospitalization among paediatric patients. SARS-CoV-2 infection may play a prothrombotic role even in children.

Aims: To assess the clinical characteristics of hospitalized paediatric patients with VTE in the years immediately preceding and following the outbreak of the SARS-CoV-2 pandemic.

Methods: In this retrospective study, we analyzed medical records from paediatric patients (age < 18 years) with a diagnosis of VTE who were hospitalized from January 1, 2018, to December 31, 2022, in the Women's and Children's Hospital of Verona, Italy.

Results: During the 5-year period 2018-2022, out of a total of 7,686 admissions were reported 51 VTE diagnoses (0.66%), of which 40 were cases of deep vein thrombosis (DVT) and 16 of superficial vein thrombosis (SVT), while 5 patients had both DVT and SVT. Almost all cases of SVT were associated with peripheral venous lines (14/16-87.5%). As regards DVT, there was a slight prevalence of male sex (24/40-60.0%). Nine events were observed in newborns ( < 1 month) and 6 events in infants (1 month-1 year). Most of events were represented by DVT in “classical” sites (26/40), but 8 were cerebral vein thromboses, which were mostly affecting newborns (5/8), and were 5 splanchnic vein thromboses. The presence of central venous lines was the most prevalent risk factor (17/40-42.5%). Seven patients had concomitant neoplastic disease and nine had recent surgery. Thrombophilia was irregularly investigated.
Considering each single year of the 5-year period, the incidence of VTE did not show significant changes, even when comparing the years of the SARS-CoV-2 pandemic with the immediately preceding years (Figure 1). None of the recorded VTE cases was positive for SARS-CoV-2 infection.

Conclusion(s): These observational data do not support SARS-CoV-2 infection as a relevant VTE risk factor in hospitalized paediatric population.