PB0636 - Stroke (Arterial Ischemic Stroke-AIS and Cerebral Sinus Venous Thrombosis-CSVT) in Greek Children: a Single-Centre Experience

Monday, June 24, 2024

13:45 – 14:45 ICT

Room: Exhibition Hall

Presenting Author(s)

AD

Athina Dettoraki, MD, MSc, PhD

Paediatrician
Haemostasis and Thrombosis Unit, Haemophilia Centre, "Aghia Sophia"Children's Hospital,Athens
Athens, Attiki, Greece

Co-Author(s)

LI

Loukia Ioannidou

PaediatricIan
Haemophilia Centre/Haemostasis and Thrombosis Unit, “Aghia Sophia” Children’s Hospital, Athens, Greece
Athens, Attiki, Greece
KD

Konstantina Dakou

Statistician
Haemophilia Centre/Haemostasis and Thrombosis Unit, “Aghia Sophia” Children’s Hospital, Athens, Greece
Athens, Attiki, Greece
AM

Alexandros Makis

Paediatrician, Professor of Paediatrics/ Paediatric Hematology
Faculty of Medicine, School of Health Sciences, University of Ioannina, Greece
Ioannina, Ioannina, Greece
AM

Aikaterini Michalopoulou

Paediatrician
Haemophilia Centre/Haemostasis and Thrombosis Unit, “Aghia Sophia” Children’s Hospital, Athens, Greece
Athens, Attiki, Greece
NP

Nefeli Papageorgiou

Paediatrician
Haemophilia Centre/Haemostasis and Thrombosis Unit, “Aghia Sophia” Children’s Hospital, Athens, Greece
Athens, Attiki, Greece
AT

Argyro Tountopoulou

Neurologist
Department of Neurology, Stroke Unit, “Eginition Hospital”, National and Kapodistrian University of Athens, Athens, Greece
Athens, Attiki, Greece
MG

Maria Gavra

Radiologist
Department of CT and MRI, “Aghia Sophia” Children’s Hospital, Athens, Greece
Athens, Attiki, Greece
ST

Sotiria Thymianou

Biologist
Haemophilia Centre/Haemostasis and Thrombosis Unit, “Aghia Sophia” Children’s Hospital, Athens, Greece
Athens, Attiki, Greece
ZK

Zoey Kapsimali

Biochemist
Haemophilia Centre/Haemostasis and Thrombosis Unit, “Aghia Sophia” Children’s Hospital, Athens, Greece
Athens, Attiki, Greece
SV

Sophia Vassilopoulou

Professor of Neurology
Department of Neurology, Stroke Unit, “Eginition Hospital”, National and Kapodistrian University of Athens, Athens, Greece
Athens, Attiki, Greece
HP

Helen Pergantou

Paediatrician, Head ofHaemophilia Centre/Haemostasis and Thrombosis Unit, “Aghia Sophia” Children’s
Haemophilia Centre/Haemostasis and Thrombosis Unit, “Aghia Sophia” Children’s Hospital, Athens, Greece
Athens, Attiki, Greece

Background: Stroke in Children (Arterial Ischemic Stroke-AIS and Cerebral Sinus Venous Thrombosis-CSVT) is rare, but causes significant morbidity and mortality.

Aims: To provide data for clinical presentation, risk factors, treatment and follow-up for children with stroke in a reference Centre for thrombosis in Greece.

Methods: Data were retrospectively collected. Children aged 28 days-18 years with first stroke between 1st/2009 and 12th/2023 were included. Healthy controls (103 children) were used as reference population, regarding thrombophilia testing. The categorical variables were described by frequency distributions and compared with x2-test.

Results: In the 14-year period, out of 384 recorded thrombosis (209 stroke-54.4%), 95 children with AIS (45.5% of all children with stroke) and 112 with CSVT were included. Stroke was more often between boys (57.9%, p< 0.05).
Most children with AIS presented with focal symptoms, particularly with acute hemiparesis (58.9%). The middle cerebral artery was the most affected vessel (37.9%).Trauma (22.1%), cardiac disorders (21.1%) and infectious diseases (20%) were the most frequently identified risk factors. Dissection was found in 8.5%. In 11.6%, no factor was identified. Almost all patients received anticoagulation (42%) or/and aspirin therapy (57%).
Regarding CSVT, the commonest presenting symptom was headache (58.9%). Papilledema was found in 21%. Infection (56.3%) was the main cause with acute otitis media with/without mastoiditis (34.8% και 42.9% respectively) being the most frequent one. Sigmoid sinus thrombosis (65.2%) was predominantly observed. Simultaneous localization in transverse and sigmoid sinuses had an increased probability of papilledema occurrence (p=0.034). All children received anticoagulation. No child had persisting neurological sequelae apart from attention deficits and mild cognitive decline.

Conclusion(s): This study provides population-based data of childhood stroke which may be useful for further research.