PB0041 - Endothelial dysfunction as predictor of atherosclerosis during a translatitudinal sea voyage in the Arctic

Sunday, June 23, 2024

13:45 – 14:45 ICT

Room: Exhibition Hall

Presenting Author(s)

Nadezda A. Vorobyeva, Phd

ptofessor
Federal State Budgetary Education Institution of Higher Education «Northern State Medical University» of the Ministry of Healthcare of the Russian Federation Arkhangelsk, Russia
Arkhangelsk, Arkhangelsk, Russia

Co-Author(s)

AV

Alyona Iv. Vorobyeva

anticoagulant clinic doctor
Federal State Budgetary Institution "National Medical Research Center for Hematology" (Northern branch) Ministry of Health of Ru
Arkhangelsk, Arkhangelsk, Russia
AV

Alexsandra S, Vorontsova

anticoagulant clinic doctor
Federal State Budgetary Institution "National Medical Research Center for Hematology" (Northern branch) Ministry of Health of Ru
Arkhangelsk, Arkhangelsk, Russia

Background: Human labor activity in the Arctic takes place in severe climatic conditions associated with cooling, atmospheric pressure drops, high humidity, photoperiodicity, low oxygen content in the air. Endothelial dysfunction is an early pathophysiological sign and an independent predictor of poor prognosis in most cardiovascular diseases.

Aims: to assess the risk of endothelial dysfunction as a trigger for early manifestations of atherosclerosis in sailors during a trans-latitude voyage in the Arctic.

Methods: A prospective clinical and laboratory study of crew members was performed during the integrated marine research expedition "Transarctic-2019". A clinical and laboratory study was carried out - the analysis of the level of metalloprotease-9, the parameters of the thrombin generation test, as well as the measurement of the thickness of the intima-media complex.

Results: There was a statistically significant increase in the level of MMP-9 in sailors after the expedition, the relationship between the level of MMP-9, thrombin generation test parameters and IMT thickening.

Conclusion(s): Under the influence of high northern latitudes on the vascular endothelium, there is a high risk of developing cardiovascular events.