PB0064 - Relationship of decreased levels of omentin-1 with insulin resistance and prothrombotic state in peripheral vascular disease

Background: Recent data suggest that various adipokines are dysregulated in peripheral vascular disease (PVD) and might be of pathophysiological and prognostic significance. Omentin-1 has been linked to obesity, type 2 diabetes mellitus, inflammation and atherosclerosis.

Aims: The purpose of this study was to examine the relationship between omentin-1 and prothrombotic factors in patients with PVD.

Methods: We consecutively evaluated 218 patients, who presented with PVD. We measured anthropometric and biochemical variables including renal function, plasma lipid profile, fasting glucose, insulin and C-peptide, PAI-1, prothrombin fragment 1+2 (F1+2), and D-dimer as markers of a prothrombotic state, and C-reactive protein (CRP) as a marker of proinflammatory state. The Homeostatic Model Assessment (HOMA) index was calculated as an index of sensitivity to insulin.

Results: Patients with PVD had significantly lower levels of omentin-1 and higher levels of D-dimer, PAI-1, F1+2 compared with healthy individuals. On univariate regression analysis, omentin-1 was inversely related with PAI-1 (r = -0.173, P< 0.05), BMI (r = -0.214, P < 0.01), HOMA index (r = -0.347, P < 0.001), CRP (r = -0.375, P < 0.001), triglycerides (r = -0.193, P< 0.01) and LDL-cholesterol (r = -0.190, P < 0.01), and directly related with HDL-cholesterol (r = 0.179, P< 0.01). A multivariate analysis included demographic and anthropometric variables and smoking habit, duration of PVD, use of antihypertensive drugs, renal function and plasma lipid levels, HOMA index and CRP indicated that omentin-1 levels are independently related with D-dimer (P < 0.01), PAI-1 and duration of PVD (both P< 0.05), LDL cholesterol (P < 0.05), HOMA index (P < 0.001), and CRP (P < 0.001).

Conclusion(s): These results indicate that a prothrombotic state is associated with decreased omentin-1 level and duration of disease, insulin resistance and a proinflammatory status in PVD. These results suggest that omentin-1 levels in PVD may be novel biochemical risk factors for atherothrombotic complications.