PB0084 - Super formula for soluble C-type lectin-like receptor 2 x D-dimer in patients with acute cerebral infarction

Background: Acute cerebral infarction (ACI) includes atherosclerotic and cardiogenic ACI and involves a thrombotic state, requiring antithrombotic treatment. However, the thrombotic state in ACI cannot be evaluated using routine hemostatic examinations. Plasma soluble C-type lectin-like receptor 2 (sCLEC-2), and D-dimer which are considered as platelet activation marker and coagulation and fibrinolysis activation marker, respectively. The super formula of sCLEC-2x D-dimer/platelet cunt (PLT) is reported to be useful for diagnosing DIC.

Aims: The usefulness of the sCLEC-2, D-dimer, sCLEC-2ｘD-dimer formula, sCLEC-2/D-dimer ratio and sCLEC-2/PLT ratio for diagnosing ACI and differentiating between atherosclerotic and cardioembolic ACI.

Methods: Plasma sCLEC-2 which was measured by a chemiluminescent enzyme immunoassay (CLEIA) and D-dimer levels were measured using the LPIA-Genesis devices in 120 patients with ACI and 130 patients without ACI.

Results: Plasma sCLEC-2 and D-dimer levels were significantly higher in patients with ACI than in those without it. The sCLEC-2 x D-dimer formula was significantly higher in patients with ACI than in those without it. A receiver operating characteristic curve showed a high sensitivity, area under the curve, and odds for diagnosing ACI in the sCLEC-2 x D-dimer formula. Although the sCLEC-2 and D-dimer levels were useful for the differential diagnosis between cardiogenic and atherosclerotic ACI, the sCLEC-2 x D-dimer formula was not useful.

Conclusion(s): sCLEC2 and D-dimer levels are useful for the diagnosis of ACI and the sCLEC2 x D-dimer formula can enhance the diagnostic ability of ACI, and sCLEC2 and D-dimer levels may be useful for differentiating between atherosclerotic and cardioembolic ACI.