PB0113 - Development of a Multi-Channel Coagulation Testing Cartridge for Microfluidic ThromboRheometry (MTR)

Background: Traditional viscoelastic hemostasis analyzers (VHA) are essential for assessing blood clotting and fibrinolysis; however, their extended test time, often exceeding one hour, presents challenges in emergency and trauma settings. Recently, we introduced a Microfluidic-Thrombo-Rheometry (MTR) system capable of significantly reducing the overall test time to less than 10 minutes. For practical clinical application, conducting multiple tests such as CK, CFF, and CKH assays concurrently is essential.

Aims: This study aims to develop a disposable cartridge capable of accommodating a minimum of three different assays, catering to the needs of emergency and trauma centers.

Methods: The multi-channel MTR testing cartridge integrates precision metering, equal distribution, efficient mixing, and uniform oscillation modules. Automated with a vacuum pump, its operation eliminates the possibility of operator errors. Featuring four channels, each connected to a pressure sensor, the cartridge allows individualized drug administration based on diagnostic targets. One test generates four simultaneous detection results.

Results: The pressure-driven multi-channel coagulation testing cartridge achieved automated precision metering, equal distribution, efficient mixing, and uniform oscillation, ensuring diagnostic accuracy across diverse clinical settings.

Conclusion(s): The innovative multi-channel coagulation testing cartridge significantly enhances diagnostic efficiency, reducing time and costs. This cartridge provides multi-dimensional diagnostic information tailored to specific clinical needs, offering robust support for timely interventions in emergent environments.