OC 58 - von Willebrand disease and immune-mediated TTP

Moderator(s)

• 

  Quintijn Bonnez, MA

  PhD Student
  Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium
  Kortrijk, West-Vlaanderen, Belgium
• 

  Joshua Muia, PhD

  Assistant Professor
  Versiti Blood Research Institute
  Milwaukee, Wisconsin, United States

Presentations:

• 09:30 – 09:45 ICT

  The molecular basis underpinning the enhanced clearance of VWF Vicenza (R1205H)
  

  Presenting Author: Ferdows Atiq, MD, MSc, PhD – Royal College of Surgeons in Ireland

  Co-Author: Orla Rawley – Molecular Hemostasis Research Group, Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.

  Co-Author: Jamie O'Sullivan – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

  Co-Author: Dearbhla Doherty – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

  Co-Author: Soracha Ward – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

  Co-Author: Alain Chion, PhD – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

  Co-Author: Ross Baker, MB BS BMedSc FRACP, FRCPA – Western Australia Centre for Thrombosis and Haemostasis, Perth Blood Institute, Murdoch University, Perth, Australia

  Co-Author: Roger J.S. Preston – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

  Co-Author: David Lillicrap, MD – Molecular Hemostasis Research Group, Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.

  Co-Author: James S. O'Donnell – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
• 09:45 – 10:00 ICT

  Allele specific knock-out of mutant Von Willebrand factor in heterozygous Von Willebrand disease type 2A patient-derived ECFCs
  

  Presenting Author: Isabel Bär, MSc – Erasmus Medical Center Rotterdam

  Co-Author: Petra Bürgisser – Hematology, Erasmus MC University Medical Center, Rotterdam, The Netherlands

  Co-Author: Iris van Moort – Erasmus MC University Medical Center, Rotterdam, The Netherlands

  Co-Author: Calvin B. van Kwawegen, MSc – Erasmus MC, University Medical Centre Rotterdam, Department of Haematology, Rotterdam, The Netherlands

  Co-Author: Jan Voorberg – Department of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands

  Co-Author: Jeroen Eikenboom – Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands

  Co-Author: Frank W.G Leebeek, MD PhD – Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands

  Co-Author: Ruben Bierings, PhD – Hematology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
• 10:00 – 10:15 ICT

  Allosteric Effects of Antibodies in Immune Thrombotic Thrombocytopenic Purpura
  

  Co-Author: Konstantine Halkidis – KUMC

  Co-Author: Chan Meng – KUMC

  Co-Author: Madison Shay – KUMC

  Co-Author: Vikram Pillai – KUMC

  Presenting Author: Long Zheng, MD, PhD – University of Kansas Medical Center
• 10:15 – 10:30 ICT

  Aptamer Inhibitor of Von Willebrand Factor Improves Vascular Patency in a Microfluidic Model of Ischemic Stroke by Prevention of Platelet-Mediated Reocclusion
  

  Presenting Author: Emily Mihalko – Trauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh

  Co-Author: Ronit Kar, BS – Trauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh

  Co-Author: Rassam Rassam – Trauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh

  Co-Author: Shahid Nimjee – Department of Neurological Surgery, The Ohio State University Medical Center

  Co-Author: Susan Shea – Trauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh
• 10:30 – 10:45 ICT

  N-glycan mediated shielding of the CUB domains of ADAMTS13 prevents binding of C-terminal antibodies in patients with immune-mediated TTP
  

  Presenting Author: Tim Postmus, MSc – Department of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands

  Co-Author: Nelly Schilder – Department of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands

  Co-Author: Juliana Ferreira de Santana – Department of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands

  Co-Author: Paul Coppo – Service d'Hématologie et CNR-MAT, Hôpital Saint-Antoine, AP-HP.6, Paris, France

  Co-Author: Bérangère Joly – Université Paris Cité, EA3518, Hôpital Lariboisière

  Co-Author: Agnès Veyradier – Service d'Hématologie Biologique and EA3518-Institut Universitaire d'Hématologie, Groupe Hospitalier Saint Louis-Lariboisière, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Diderot, Paris, France

  Co-Author: Karen Vanhoorelbeke – Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium

  Co-Author: Jan Voorberg – Department of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands