OC 36 - Joint health pathophysiological mechanisms

Moderator(s)

• 

  Roberta Gualtierotti, PhD

  Associate Professor
  Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy; Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan, Italy
  Milan, Lombardia, Italy
• 

  Stacy Croteau, MD, MMS

  Boston Children’s Hospital, Massachusetts, United States

Presentations:

• 09:30 – 09:45 ICT

  FIX is localised in the vessel wall and can generate thrombin when in complex with collagen IV in human synovial tissues
  

  Presenting Author: Gael Morrow, PhD – Robert Gordon University

  Co-Author: Mike Laffan – Imperial College London, London. UK

  Co-Author: Nicola Curry, MD, FRCP, FRCPath – University of Oxford
• 09:45 – 10:00 ICT

  Platelet rich plasma modulates macrophages polarization in the context of Chronic Hemophilic Synovitis
  

  Presenting Author: Paula Oneto, PhD – Institute of Experimental Medicine (IMEX-ANM-CONICET)

  Co-Author: Maria Eulalia Landro – Hemophilia Foundation

  Co-Author: Carla Daffunchio – Hemophilia Foundation

  Co-Author: Ana Laura Douglas Price – Hemophilia Foundation

  Co-Author: Horacio Caviglia – Hemophilia Foundation

  Co-Author: Eugenio Antonio Carrera Silva – Institute of Experimental Medicine (IMEX-ANM-CONICET)
• 10:00 – 10:15 ICT

  Type-I Interferon promotes neutrophil-dependent Joint Damage in Hemophilia A
  

  Presenting Author: Tomasz W. Kaminski, PharmD – Versiti Blood Research Institute

  Co-Author: Omika Katoch – Versiti Blood Research Institute

  Co-Author: Nicholas Swendrowski – Versiti Blood Research Institute

  Co-Author: Tomasz Brzoska – Vascular Medicine Institute, University of Pittsburgh

  Co-Author: Margaret V. Ragni – Department of Medicine, University of Pittsburgh

  Co-Author: Prithu Sundd – Versiti Blood Research Institute
• 10:15 – 10:30 ICT

  miRNA expression profiles as a potential biomarker of joint and bone health in haemophilia A
  

  Co-Author: Alexandre Leuci – UR 4609 Hemostase et Thrombose, Universite Lyon 1

  Co-Author: Muriel Marano – UR 4609 Hemostase et Thrombose, Universite Lyon 1

  Co-Author: Marjorie Millet – INSERM UMR 1033, Université de Lyon

  Co-Author: Stephanie Desage – Centre de Référence National de l’Hémophilie, Unité d’Hémostase Clinique, Hopital Louis Pradel

  Co-Author: Anne Lienhart – Centre de Référence National de l’Hémophilie, Unité d’Hémostase Clinique, Hopital Louis Pradel

  Co-Author: Roland Chapurlat – INSERM UMR 1033, Université de Lyon

  Presenting Author: Yesim G. Dargaud, MD,PhD – UR 4609 Hemostase et Thrombose, Universite Lyon 1
• 10:30 – 10:45 ICT

  Factor VIII is a regulator of angiogenesis and a promoter of endothelial barrier stability
  

  Co-Author: Cristina Olgasi – University of Piemonte Orientale, Department Translational Medicine

  Co-Author: Alessia Cucci, PhD – University of Piemonte Orientale, Department of Health Sciences

  Co-Author: Simone Assanelli – Department of Health Sciences, University of Piemonte Orientale, Novara, Italy

  Co-Author: Chiara Sgromo – Department of Health Sciences, University of Piemonte Orientale

  Co-Author: Giorgia Venturin – University of Piemonte Orientale, Department of Health Sciences

  Co-Author: Chiara Borsotti – Department of Health Sciences, University of Piemonte Orientale

  Co-Author: Roberto Santi – Dipartimento Attività Integrate Ricerca Innovazione, Azienda Ospedaliera Universitaria SS. Antonio e Biagio e C. Arrigo

  Presenting Author: Antonia Follenzi, MD, PhD – University of Piemonte Orientale, Department of Health Sciences