OC 48 - Megakaryocytes: What's under the hood?

Moderator(s)

• 

  Kerstin Jurk, PhD

  Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University, Mainz, Germany
  Mainz, Rheinland-Pfalz, Germany
• 

  Alessandra Balduini, MD

  MD, PhD
  Department of Molecular Medicine
  University of Pavia, Pavia, Italy
  Pavía, Lombardia, Italy

Presentations:

• 14:45 – 15:00 ICT

  Vps34 localizes to the nucleolus and mediates megakaryocyte maturation via ribosome biogenesis
  

  Co-Author: Ivana Bertovic – University of Rijeka, Faculty of Biotechnology and Drug Development

  Co-Author: Sladana Bursac – University of Rijeka, Faculty of Medicine, Department of Molecular Medicine and Biotechnology

  Co-Author: Sinisa Volarevic – University of Rijeka, Faculty of Medicine, Department of Molecular Medicine and Biotechnology

  Presenting Author: Antonija Jurak Begonja, PhD – University of Rijeka, Faculty of Biotechnology and Drug Development
• 15:00 – 15:15 ICT

  Aging-Related Changes in Megakaryocyte Progenitors: Single-Cell Transcriptomics Study
  

  Presenting Author: Pratintip Lee, MD – Center for Molecular Cardiology, University of Zurich, Cantonal Hospital Baden, Switzerland

  Co-Author: Soheil Saeedi Saravi – Center for Translational and Experimental Cardiology, University Hospital Zurich

  Co-Author: Meret Allemann – Center for Molecular Cardiology, University of Zurich, Cantonal Hospital Baden, Switzerland

  Co-Author: Carolina Balbi – Center for Molecular Cardiology, University of Zurich, Cantonal Hospital Baden, Switzerland

  Co-Author: Tongtong Wang – Institute of Food, Nutrition and Health, ETH Zurich

  Co-Author: Christian Wolfrum – Institute of Food, Nutrition and Health, ETH Zurich

  Co-Author: Jürg Hans Beer – Center for Molecular Cardiology, University of Zurich, Cantonal Hospital Baden, Switzerland
• 15:15 – 15:30 ICT

  Contractility of iPSC-derived megakaryocyte precursors at different stages of development
  

  Co-Author: Oleg V. Kim – Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

  Co-Author: Rustem I. Litvinov – Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

  Co-Author: Deborah L. French – Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia

  Co-Author: Lawrence F. Brass – Department of Hematology and Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

  Presenting Author: John W. Weisel – Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
• 15:30 – 15:45 ICT

  Loss of PP1β leads to abnormal megakaryocyte development, severe thrombocytopenia, osteosclerosis and myelofibrosis
  

  Presenting Author: Gabriel H. M Araujo – University Hospital Würzburg

  Co-Author: Maximilian Englert – University Hospital Würzburg

  Co-Author: Audrey Chang – UT Southwestern Medical Center

  Co-Author: Angus Nairn – Yale School of Medicine

  Co-Author: Bernhard Nieswandt – University Hospital Würzburg

  Co-Author: Zoltan Nagy, PhD – University Hospital Würzburg
• 15:45 – 16:00 ICT

  Crucial role of casein kinase 1α in megakaryocyte cytoskeletal rearrangements and thrombopoiesis
  

  Presenting Author: Ferdinand Kollotzek, M. Sc. – Department of Cardiology and Angiology, University of Tuebingen

  Co-Author: Melina Fischer, MSc – Department of Cardiology and Angiology, University of Tuebingen

  Co-Author: Patrick Münzer – Department of Cardiology and Angiology, University of Tuebingen

  Co-Author: Mailin-Christin Manke – Department of Cardiology and Angiology, University of Tuebingen

  Co-Author: Vanessa Göb – 5Institute for Experimental Biomedicine, University Hospital Würzburg

  Co-Author: Kristina Mott – University Hospital Würzburg, Department of Experimental Biomedicine I, Würzburg, Germany

  Co-Author: Irene Gonzalez Menendez – Institute of Pathology, University of Tübingen, Germany

  Co-Author: Leticia Quintanilla de Fend – Institute of Pathology, University of Tübingen, Germany

  Co-Author: Andreas Mack – Institute of Anatomy, University of Tübingen, Germany

  Co-Author: Harald Schulze – University Hospital Würzburg, Department of Experimental Biomedicine I, Würzburg, Germany

  Co-Author: David Stegner – Institute for Experimental Biomedicine, University Hospital Würzburg

  Co-Author: Robert Ahrends – Department of Analytical Chemistry, University of Vienna, Austria

  Co-Author: Oliver Borst – Department of Cardiology and Angiology, University of Tuebingen