OC 25 - Intrinsic routes of coagulation activation

Moderator(s)

• AM

  Adarsh Mohapatra, MSc

  PhD student
  Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands
  Maastricht, Limburg, Netherlands
• 

  Helen Philippou, PhD

  Professor
  LICAMM
  University of Leeds.
  Leeds, England, United Kingdom

Presentations:

• 14:45 – 15:00 ICT

  Thiol isomerase ERp46 catalyzes the disulfide formation of coagulation factor XII enhancing its activation
  

  Presenting Author: Aizhen Yang, PhD – The Cyrus Tang Hematology Center, Soochow University

  Co-Author: Yaqiong Zhang – Soochow Universtiy

  Co-Author: Yaowei Sun – Soochow Universtiy

  Co-Author: Zhenzhen Zhao, MD – Soochow Universtiy

  Co-Author: Zhipu Luo – Soochow Universtiy

  Co-Author: Yue Han – The First Affiliated Hospital of Soochow University

  Co-Author: Depei Wu – The First Affiliated Hospital of Soochow University

  Co-Author: Yi Wu, MD, PhD – Soochow University
• 15:00 – 15:15 ICT

  Amyloid fibrils trigger plasma clotting by activating the intrinsic pathway of blood coagulation and can explain intracardiac thrombosis in Transthyretin (ATTR) and Ig-Light Chain Amyloidosis (AL)
  

  Presenting Author: Alessia Dei Rossi – Dept. of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy

  Co-Author: Laura Acquasaliente – Dept. of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy

  Co-Author: Ornella Leone – IRCCS University Hospital of Bologna, Bologna, Italy

  Co-Author: Serena Toffanin – Università di Padova

  Co-Author: Paolo Simioni, MD, PhD – University of Padova, Padova University Hospital

  Co-Author: Vincenzo De Filippis – Dept. of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy

  Co-Author: Guglielmo Verona – Center for Amyloidosis, University College London, London, United Kingdom
• 15:15 – 15:30 ICT

  The Acinetobacter baumannii Secreted Protease CpaA Inhibits Factor XII-mediated Neutrophil Activation
  

  Presenting Author: Dillon Bohinc – Case Western Reserve University

  Co-Author: Kara Bane – Case Western Reserve University

  Co-Author: Kris Blair – Fred Hutch/University of Washington/Seattle Children’s Cancer Consortium

  Co-Author: Eduarda Grinsztejn – Medicine Service, Section of Hematology-Oncology, Louis Stokes Veterans Administration Medical Center

  Co-Author: Steven Marshall – 5Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center

  Co-Author: Robert Bonomo – Department of Medicine, Division of Infectious Diseases, Case Western Reserve University School of Medicine,

  Co-Author: Daniel Lawrence – Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical School

  Co-Author: Maria Sandkvist – 1Department of Microbiology and Immunology, University of Michigan Medical School

  Co-Author: Evi X. Stavrou, MD – Department of Medicine, Hematology and Oncology Division, Case Western Reserve University (CWRU) School of Medicine
• 15:30 – 15:45 ICT

  Coagulation factor XI contributes to vascular dysfunction and cardiac inflammation in ischemia/reperfusion injury in mice with excess neurohormonal activation
  

  Co-Author: Qi Luo – Medical Center of Mainz University

  Co-Author: Melania Aluia – Medical center of Mainz university

  Co-Author: Michael Molitor – Medical center of Mainz university

  Presenting Author: Phillip Wenzel, Professor, MD – University Medical Center Mainz
• 15:45 – 16:00 ICT

  Characterization of Interactions Between Skeletal Muscle Myosin and Activated Factor XI
  

  Presenting Author: Chih-Jen Yang, MD – Oregon Health & Science University

  Co-Author: John Griffin – The Scripps Research Institute

  Co-Author: Hiroshi Deguchi – The Scripps Research Institute

  Co-Author: David Gailani, MD – Vanderbilt University Medical Center

  Co-Author: Owen McCarty – Oregon Health & Science University

  Co-Author: Cristina Puy – Oregon health & science university