OC 43 - New strategies for reversal and prevention of bleeding

Moderator(s)

• 

  Joseph Shaw, MD, MSc, FRCPC

  Hematologist
  The Ottawa Hospital
  Ottawa, Ontario, Canada
• 

  James Winearls, BSc, MBBS, FRCP (UK), FCICM

  Clinician
  Gold Coast University Hospital
  Gold Coast, Queensland, Australia

Presentations:

• 14:45 – 15:00 ICT

  A novel bleeding model in monkeys to assess efficacy of VMX-C001 for bypassing of FXa-DOAC anticoagulation
  

  Presenting Author: Daniël Verhoef – Division of Thrombosis and Hemostasis, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands

  Co-Author: Pieter Reitsma – Division of Thrombosis and Hemostasis, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands

  Co-Author: Viola Strijbis – VarmX, Leiden, The Netherlands

  Co-Author: Tainá Gomes – VarmX, Leiden, The Netherlands

  Co-Author: Jan Öhrström – VarmX, Leiden, The Netherlands

  Co-Author: Ged Short – VarmX, Leiden, The Netherlands

  Co-Author: Michael Zörer – VarmX, Leiden, The Netherlands

  Co-Author: Jeffrey Lawson – VarmX, Leiden, The Netherlands
• 15:00 – 15:15 ICT

  CAY001, a synthetic short-chain polyphosphate (polyP) complexed with silica nanoparticle (SNP), has pro-hemostatic activities as assessed by in vitro and ex vivo studies
  

  Presenting Author: Damien Kudela, PhD – Cayuga Biotech, Inc.

  Co-Author: Genmin Lu – Cayuga Biotech, Inc.

  Co-Author: Stephanie Smith – University of Michigan

  Co-Author: Andrea Ashford-Hicks – Cayuga Biotech, Inc.

  Co-Author: James H. Morrissey – Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA
• 15:15 – 15:30 ICT

  Thrombin Shanghai Mutant Grafted by Bacteria-engineered Porous Sponge for Perioperative Bleeding
  

  Presenting Author: ke Zhang, MS – Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

  Co-Author: Xi Wu, MD – Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

  Co-Author: Luhan Bao – Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, P. R. China.

  Co-Author: Changming chen, PhD candidate – Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

  Co-Author: Wenguo Cui – Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, P. R. China.

  Co-Author: Jing Dai – Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
• 15:30 – 15:45 ICT

  Novel synthetic sulfonate-based di- and triblock polymers with anticoagulant activity: mechanism of action, efficacy and safety
  

  Co-Author: Justyna Swieton – Department of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland

  Co-Author: Joanna Miklosz – Department of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland

  Co-Author: Natalia Bielicka – Department of Biopharmacy and Radiopharmacy, Medical University of Bialystok, Bialystok, Poland

  Co-Author: Aleksandra Frackiewicz – Department of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland

  Co-Author: Karol Depczynski – Department of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland

  Co-Author: Marta Stolarek – Faculty of Chemistry, Jagiellonian University, Krakow, Poland

  Co-Author: Piotr Bonarek – Faculty of Chemistry, Jagiellonian University, Krakow, Poland

  Co-Author: Kamil Kaminski – Faculty of Chemistry, Jagiellonian University, Krakow, Poland

  Co-Author: Shin-Ichi Yusa – Department of Applied Chemistry, University of Hyogo, Hyogo, Japan

  Co-Author: Anna Gromotowicz-Poplawska – Department of Biopharmacy and Radiopharmacy, Medical University of Bialystok, Bialystok, Poland

  Co-Author: Krzysztof Szczubialka – Faculty of Chemistry, Jagiellonian University, Krakow, Poland

  Co-Author: Dariusz Pawlak – Department of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland

  Co-Author: Andrzej Mogielnicki, PhD – Department of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland

  Presenting Author: Bartlomiej Kalaska, PhD – Department of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland
• 15:45 – 16:00 ICT

  Using technology to improve patient care: A novel electronic dashboard within an Anticoagulation Stewardship service to promote safety across a large hospital network in Australia.
  

  Presenting Author: Emma J. Leitinger, MBBS BMedSci FRACP FRCPA – Monash Health

  Co-Author: Nadishani Ratnayake – Monash Health

  Co-Author: Simone Taylor – Monash Health

  Co-Author: Nicholas Ling – Monash Health

  Co-Author: Katherine Wilson – Monash Health

  Co-Author: Tania Duncan – Monash Health

  Co-Author: Jasmine Singh – Monash Health

  Co-Author: Hiu Lam Agnes Yuen – Monash Medical Centre

  Co-Author: Charithani Keragala, MBBS (Hons), PhD, FRACP, FRCPA – Monash University

  Co-Author: Kay Htun – Monash Health

  Co-Author: Zahraa Hamad – Monash University

  Co-Author: Emily Chen – Monash University

  Co-Author: Ben Kuppe – Monash Health

  Co-Author: Mark Sheppard – Monash Health

  Co-Author: Sanjeev Chunilal – Monash Health

  Co-Author: Susan Brown – Monash Health