OC 07 - Components of prothrombinase

Moderator(s)

• 

  Tilman Hackeng, PhD

  Professor
  Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University
  Maastricht, Netherlands
• 

  Josefin Ahnström

  Senior Lecturer in Haematology
  Imperial College London
  London, England, United Kingdom

Presentations:

• 13:00 – 13:15 ICT

  The clearance receptor CLEC4M regulates plasma factor V levels through factor V binding and internalization
  

  Presenting Author: Adarsh K. Mohapatra, MSc – Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands

  Co-Author: Pierre Morange, MD, PhD – Aix-Marseille University

  Co-Author: Elisabetta Castoldi – Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands

  Co-Author: Franck Peiretti – C2VN, INRAE, INSERM Aix-Marseille University, Marseille, France
• 13:15 – 13:30 ICT

  Engineering a membrane-independent human prothrombinase through parsimonious mutation of factor Xa
  

  Presenting Author: Fatma Isik Ustok, PhD – University of Cambridge

  Co-Author: James A. Huntington, PhD – University of Cambridge
• 13:30 – 13:45 ICT

  Structural basis of prothrombin recognition by a Type-I anti-prothrombin antiphospholipid antibody revealed by cryo-EM.
  

  Presenting Author: Suresh Kumar, PhD – Saint Louis University School of Medicine

  Co-Author: Vittorio Pengo – Department of Cardiac-Thoracic-Vascular Sciences and Public Health University of Padova

  Co-Author: Robert Flaumenhaft, MD, PhD – BIDMC/Harvard Medical School

  Co-Author: Nicola Pozzi – Saint Louis University School of Medicine
• 13:45 – 14:00 ICT

  Structural biology of substrate recognition by tissue factor/factor VIIa
  

  Presenting Author: Josepha C. Sedzro, PhD – Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA

  Co-Author: Fabienne Birkle – Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA

  Co-Author: Katarina Meze – Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA

  Co-Author: Amanda Photenhauer – Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA

  Co-Author: Xueyuan Peng – Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA

  Co-Author: Melanie P. Muller – Department of Biochemistry, Center for Biophysics and Quantitative Biology, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA

  Co-Author: Sarah Kearns – Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA

  Co-Author: Michael A. Cianfrocco – Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA, Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA

  Co-Author: Emad Tajkhorshid – Department of Biochemistry, Center for Biophysics and Quantitative Biology, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA

  Co-Author: Melanie D. Ohi – Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA, Department of Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI, USA

  Co-Author: James H. Morrissey – Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA
• 14:00 – 14:15 ICT

  A 3.3Å cryo-EM structure of an engineered high-affinity human prothrombinase complex
  

  Co-Author: Fatma Isik Ustok, PhD – University of Cambridge

  Co-Author: Alexandre Faille – University of Cambridge

  Presenting Author: James A. Huntington, PhD – University of Cambridge